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Unlike many naturally occurring peptides, BPC-157 is produced synthetically for controlled research applications

doi:10.1163/156856208784909435

CPP-CAND disrupts FOXO4-p53 foci and induces apoptosis through caspase-dependent pathways FOXO4 is progressively recruited to euchromatin foci following senescence induction and is retained in the nucleus of senescent cells through its interaction with p53, contributing to the maintenance of the senescent state 34